Perineural Injections

Perineural Injections, otherwise known as Lyftogt Technique or Neural Prolotherapy, are an effective treatment for pain originating around small surface nerves and the fascia layer. These are very superficial injections using 5% Dextrose. This almost immediately shuts off production of painful stimuli and helps reduce nerve swelling, resulting in near immediate pain relief.​

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The exact mechanism of action is unknown, but it is postulated that dextrose works at the cellular level on the TRVP1 receptors to decrease Substance P and other pain producing chemicals. Dextrose is also thought to work on ion channels in the affected nerve, aiding in healing at the cell level. Lastly, the hydrodissection effect of injection allows the nerve to return to normal sliding through fascial openings.

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The first injections can relieve pain for a few hours to a few weeks. Pain will almost certainly return at some point, to some extent. Each treatment should result in longer lasting, more robust pain relief.